Scientist II, Immuno-Oncology

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Astellas Institute for Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma Inc and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.

AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell-based therapy research programs. AIRM is headquartered in Massachusetts.

Astellas is announcing a Scientist II, Immuno-Oncology opportunity at their Astellas Institute for Regenerative Medicine (AIRM) site in Westborough, MA.

Purpose:

We are seeking a highly motivated and talented Scientist to join our R&D team and play a key role in developing a human pluripotent stem cell (PSC)-derived CAR cell therapy for clinical applications. The successful candidate will have a track record of success in a collaborative research environment with proficiency in oncology animal models, various standard immunology and cell biology techniques and a proven ability to plan and execute experiments and analyze data independently. The Scientist will apply their knowledge of immuno-oncology towards the generation of an exciting cell therapy opportunity.

Essential Job Responsibilities:

• Performs research and/or development in collaboration with others.

• Makes detailed observations, analyzes data and interprets results.

• Exercises technical discretion in the design, execution and interpretation of experiments that contribute to project goals.

• Prepares technical reports, summaries, protocols, and quantitative analyses.

• Contributes to project process within his/her scientific discipline.

• Investigates, creates and develops new methods and technologies for project advancement.

• Maintains high level of professional expertise through familiarity with scientific literature.

• Uses professional concepts in accordance with company objectives to solve complex problems in creative and effective ways.

• Initiate and coordinate in vivo solid tumor models.

Quantitative Dimensions:

• Ability to independently and efficiently perform laboratory experiments.

• Demonstrates clear conceptual understanding of project goals, experimental design, data analysis and troubleshooting.

• Excellent communication and interpersonal skills.

• Demonstrates effective collaboration with team members and other teams.

Organizational Context:

• Communicates with other members of multidisciplinary teams.

Qualifications

Required:

• Education: BS with 10 , MS with 7 , or Ph.D. with 3 years laboratory experience.

• Hands-on experience with animal models of solid tumors including s.c. and i.p. implantation.

• Demonstrated industry experience or academic achievement, e.g., strong publication record or drug development portfolio.

• Experience with immune cell characterization and profiling using flow cytometry, immunofluorescence, and cell isolation techniques.

• Excellent written and oral communication skills.

• Expertise handling animals and performing IV, SC, and IP injections.

Preferred:

• Experience with the CT26 tumor model or other immunocompetent animal studies.

• Demonstrated ability to perform BLI measurements of luciferase tumors.

• Hands on experience with in vivo analysis of TME factors, tumor development, and immune cell trafficking.

• Familiarity with lentiviral transduction of immune cells.

• Experience with human or mouse PSC manipulation is welcome but not required.

Benefits:

• Medical, Dental and Vision Insurance

• Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

• 401(k) match and annual company contribution

• Company paid life insurance

• Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

• Long Term Incentive Plan for eligible positions

• Referral bonus program

*LI-TD

Category IRM-Research

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans